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PLK3 | |||||||||||||||||
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Identifiers | |||||||||||||||||
Aliases | PLK3, CNK, FNK, PRK, PLK-3, polo like kinase 3 | ||||||||||||||||
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Orthologs | |||||||||||||||||
Species | Human | Mouse | |||||||||||||||
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RefSeq (mRNA) |
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RefSeq (protein) |
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Location (UCSC) | Chr 1: 44.8 – 44.81 Mb | Chr 4: 117.13 – 117.13 Mb | |||||||||||||||
PubMed search | [3] | [4] | |||||||||||||||
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Polo-like kinase 3 (Drosophila), also known as PLK3, is an enzyme which in humans is encoded by the PLK3gene.[5][6]
Function[edit]
Cytokine-inducible kinase is a putative serine/threonine kinase. CNK contains both a catalytic domain and a putative regulatory domain. It may play a role in regulation of cell cycle progression and tumorigenesis.[5]
Interactions[edit]
PLK3 has been shown to interact with:
- CDC25C,[7]
- CHEK2,[8] and
- P53.[8][9]
References[edit]
- ^ abcGRCh38: Ensembl release 89: ENSG00000173846 - Ensembl, May 2017
- ^ abcGRCm38: Ensembl release 89: ENSMUSG00000028680 - Ensembl, May 2017
- ^'Human PubMed Reference:'.
- ^'Mouse PubMed Reference:'.
- ^ ab'Entrez Gene: PLK3 polo-like kinase 3 (Drosophila)'.
- ^Li B, Ouyang B, Pan H, Reissmann PT, Slamon DJ, Arceci R, Lu L, Dai W (August 1996). 'Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas'. J. Biol. Chem. 271 (32): 19402–8. doi:10.1074/jbc.271.32.19402. PMID8702627.
- ^Ouyang B, Li W, Pan H, Meadows J, Hoffmann I, Dai W (Oct 1999). 'The physical association and phosphorylation of Cdc25C protein phosphatase by Prk'. Oncogene. 18 (44): 6029–36. doi:10.1038/sj.onc.1202983. PMID10557092.
- ^ abBahassi el M, Conn CW, Myer DL, Hennigan RF, McGowan CH, Sanchez Y, Stambrook PJ (Sep 2002). 'Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways'. Oncogene. 21 (43): 6633–40. doi:10.1038/sj.onc.1205850. PMID12242661.
- ^Xie S, Wu H, Wang Q, Cogswell JP, Husain I, Conn C, Stambrook P, Jhanwar-Uniyal M, Dai W (Nov 2001). 'Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway'. J. Biol. Chem. 276 (46): 43305–12. doi:10.1074/jbc.M106050200. PMID11551930.
Further reading[edit]
- Li B, Ouyang B, Pan H, Reissmann PT, Slamon DJ, Arceci R, Lu L, Dai W (1996). 'Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas'. J. Biol. Chem. 271 (32): 19402–8. doi:10.1074/jbc.271.32.19402. PMID8702627.
- Peng CY, Graves PR, Thoma RS, Wu Z, Shaw AS, Piwnica-Worms H (1997). 'Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216'. Science. 277 (5331): 1501–5. doi:10.1126/science.277.5331.1501. PMID9278512.
- Ouyang B, Pan H, Lu L, Li J, Stambrook P, Li B, Dai W (1997). 'Human Prk is a conserved protein serine/threonine kinase involved in regulating M phase functions'. J. Biol. Chem. 272 (45): 28646–51. doi:10.1074/jbc.272.45.28646. PMID9353331.
- Kauselmann G, Weiler M, Wulff P, Jessberger S, Konietzko U, Scafidi J, Staubli U, Bereiter-Hahn J, Strebhardt K, Kuhl D (1999). 'The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity'. EMBO J. 18 (20): 5528–39. doi:10.1093/emboj/18.20.5528. PMC1171621. PMID10523297.
- Ouyang B, Li W, Pan H, Meadows J, Hoffmann I, Dai W (1999). 'The physical association and phosphorylation of Cdc25C protein phosphatase by Prk'. Oncogene. 18 (44): 6029–36. doi:10.1038/sj.onc.1202983. PMID10557092.
- Shieh SY, Ahn J, Tamai K, Taya Y, Prives C (2000). 'The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites'. Genes Dev. 14 (3): 289–300. PMC316358. PMID10673501.
- Dai W, Li Y, Ouyang B, Pan H, Reissmann P, Li J, Wiest J, Stambrook P, Gluckman JL, Noffsinger A, Bejarano P (2000). 'PRK, a cell cycle gene localized to 8p21, is downregulated in head and neck cancer'. Genes Chromosomes Cancer. 27 (3): 332–6. doi:10.1002/(SICI)1098-2264(200003)27:3<332::AID-GCC15>3.0.CO;2-K. PMID10679924.
- Matsuoka S, Rotman G, Ogawa A, Shiloh Y, Tamai K, Elledge SJ (2000). 'Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro'. Proc. Natl. Acad. Sci. U.S.A. 97 (19): 10389–94. doi:10.1073/pnas.190030497. PMC27034. PMID10973490.
- Holtrich U, Wolf G, Yuan J, Bereiter-Hahn J, Karn T, Weiler M, Kauselmann G, Rehli M, Andreesen R, Kaufmann M, Kuhl D, Strebhardt K (2000). 'Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages'. Oncogene. 19 (42): 4832–9. doi:10.1038/sj.onc.1203845. PMID11039900.
- Bulavin DV, Higashimoto Y, Popoff IJ, Gaarde WA, Basrur V, Potapova O, Appella E, Fornace AJ (2001). 'Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase'. Nature. 411 (6833): 102–7. doi:10.1038/35075107. PMID11333986.
- Xie S, Wu H, Wang Q, Cogswell JP, Husain I, Conn C, Stambrook P, Jhanwar-Uniyal M, Dai W (2001). 'Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway'. J. Biol. Chem. 276 (46): 43305–12. doi:10.1074/jbc.M106050200. PMID11551930.
- Latonen L, Taya Y, Laiho M (2001). 'UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts'. Oncogene. 20 (46): 6784–93. doi:10.1038/sj.onc.1204883. PMID11709713.
- Ahn JY, Li X, Davis HL, Canman CE (2002). 'Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain'. J. Biol. Chem. 277 (22): 19389–95. doi:10.1074/jbc.M200822200. PMID11901158.
- Sumara I, Vorlaufer E, Stukenberg PT, Kelm O, Redemann N, Nigg EA, Peters JM (2002). 'The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase'. Mol. Cell. 9 (3): 515–25. doi:10.1016/S1097-2765(02)00473-2. PMID11931760.
- Wang Q, Xie S, Chen J, Fukasawa K, Naik U, Traganos F, Darzynkiewicz Z, Jhanwar-Uniyal M, Dai W (2002). 'Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity'. Mol. Cell. Biol. 22 (10): 3450–9. doi:10.1128/MCB.22.10.3450-3459.2002. PMC133784. PMID11971976.
- Bahassi el M, Conn CW, Myer DL, Hennigan RF, McGowan CH, Sanchez Y, Stambrook PJ (2002). 'Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways'. Oncogene. 21 (43): 6633–40. doi:10.1038/sj.onc.1205850. PMID12242661.
- Tsvetkov L, Xu X, Li J, Stern DF (2003). 'Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody'. J. Biol. Chem. 278 (10): 8468–75. doi:10.1074/jbc.M211202200. PMID12493754.
- Xie S, Wu H, Wang Q, Kunicki J, Thomas RO, Hollingsworth RE, Cogswell J, Dai W (2003). 'Genotoxic stress-induced activation of Plk3 is partly mediated by Chk2'. Cell Cycle. 1 (6): 424–9. doi:10.4161/cc.1.6.271. PMID12548019.
- Bahassi el M, Hennigan RF, Myer DL, Stambrook PJ (2004). 'Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation'. Oncogene. 23 (15): 2658–63. doi:10.1038/sj.onc.1207425. PMID14968113.
Retrieved from 'https://en.wikipedia.org/w/index.php?title=PLK3&oldid=799433603'
(Redirected from PKP PLK)
JSC | |
Industry | Rail transport |
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Founded | 2001 |
Headquarters | Warsaw, Poland |
Key people | Ireneusz Merchel CEO |
Services | Rail line construction Rail traffic control |
Revenue | 5.717 billion zł[1] (2017) |
15.14 million zł[2] (2017) | |
Total assets | 53.229 billion zł[3] (2017) |
Number of employees | 39 349 (2017) |
Parent | PKP Group |
Website | www.plk-sa.pl |
PKP Polskie Linie Kolejowe S.A. is a company of the PKP Group and is the Polish railway infrastructure manager, responsible for maintenance of rail tracks, conducting the trains across country, scheduling train timetables and management of railway land.
The company was founded after dividing Polskie Koleje Państwowe (national rail operator) into several separate companies to meet European Union Standards.
References[edit]
- ^'Raport roczny PKP (2017)'(PDF) (in Polish). PKP. Retrieved 22 January 2019.
- ^'Raport roczny PKP (2017)'(PDF) (in Polish). PKP. Retrieved 22 January 2019.
- ^'Raport roczny PKP (2017)'(PDF) (in Polish). PKP. Retrieved 22 January 2019.
See also[edit]
Retrieved from 'https://en.wikipedia.org/w/index.php?title=PKP_Polskie_Linie_Kolejowe&oldid=879669138'